One of the biggest challenges in drug development is delivering the right therapy to the right cells in the right tissue of the body. The combination of molecular engineering and the route of administration can have a profound impact on a treatment’s therapeutic index. We have developed methods for delivering our exosome therapeutics to the right body compartment through systemic or regional dosing to ensure enough drug gets to the desired target while limiting potential off-target side effects.
Harnessing the Natural Behavior of Exosomes
Research has shown that exosomes deliver information within and between organs of the body. We have demonstrated the therapeutic potential of exosomes in preclinical models with systemic, subcutaneous, inhaled, intratumoral and intrathecal delivery.
Targeted Administration to Address Specific Needs
Targeted dosing concentrates exosome therapeutics to the desired compartment while limiting off-target activity. Combined with Codiak’s proprietary exosome engineering, our compartmental dosing approach has the potential to markedly improve the efficacy and safety of our exosome therapeutic candidates.