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For decades, researchers have recognized the enormous potential of exosomes. However, the ability to rationally engineer exosomes with predictable and reproducible therapeutic effects has remained an elusive goal. Through rigorous research to solve this challenge, Codiak developed the engEx Platform, which enables us to engineer exosomes with distinct properties, load them with various types of therapeutic molecules and direct tropism so they reach specific target cells.

Coupled with our proprietary manufacturing process, we believe our technology is enabling us to unlock the true therapeutic potential of exosomes.

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Engineering Exosomes With Distinct Properties

Through our engEx Platform, we use two strategies to incorporate a wide range of therapeutic molecules into our exosomes: molecular engineering and exogenous drug loading. These strategies can be leveraged independently or combined for versatility. The result: engineered exosomes purpose-built to achieve an intended therapeutic effect in a select group of target cells.

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Endogenous 2x

Molecular Engineering: Proteins

Using precision cell engineering through engEx, we can program cells to make customized exosomes. These exosomes incorporate our proprietary scaffold proteins that enable us to tether therapeutic molecules on the surface of the exosome (membrane) or the inside of the exosome (lumen).

Exogenous 2x

Exogenous Drug Loading: Small Molecules or Nucleic Acids

Utilizing our proprietary manufacturing process, we can load highly purified exosomes with small molecules or nucleic acids, further expanding the options for designing exosomes with specific properties to deliver numerous classes of drugs.

Engineering innovation

Our discovery of two highly abundant, naturally occurring exosome proteins enable us to precisely engineer exosomes as biologic medicines. Working with highly purified exosomes, we identified two novel classes of exosome-associated proteins. We use these proteins – PTGFRN and BASP-1 – as scaffolds to direct proteins of interest (targeting ligands and therapeutic molecules) to the surface or the lumen of exosomes.

Our proprietary scaffold proteins provide significant advantages over previously reported exosome scaffolds and have predictable and reproducible properties.

Load the Surface

We use PTGFRN to decorate the exosome surface with a wide range of proteins.

Load the Lumen

We use the elements of BASP-1 to incorporate various proteins into the exosome lumen.