Cellular Communicators

Exosomes are nanometer-sized membrane sacs, or vesicles, that are released and received by nearly all cells in the body. Acting as a cellular communication system, exosomes deliver various molecules – DNA, RNA, proteins and lipids – from cell to cell.

Exosome Biology

TRAFFICKING MESSAGES
Unique protein and carbohydrate molecules on the surface of exosomes allow them to traffic in the body and be taken up efficiently by cells.
DELIVERING INSTRUCTIONS
Upon delivery, the exosome’s cargo can change the biological function of the recipient cell according to the instructions encoded by the payload.
SPECIFIC TARGETS
Exosomes do not randomly distribute, but rather appear to seek specific cellular targets. Directing their path to precise cells creates the powerful potential to deliver diverse therapies to intended targets, modulating cellular function to achieve therapeutic benefit

Two inherent characteristics of exosomes offer important opportunities for drug delivery: their membrane composition and immune-silent nature.

Membrane Composition

The complex membrane composition of exosomes allows them to deliver their biological messages and thus change the behavior of the recipient cells in two ways: by efficiently entering target cells or by interacting with proteins on the cell’s surface.

Immune Silent

Exosomes are, by their very nature, believed to evade the immune system, which allows exosomes to move through the various sensors the body uses to detect and halt the spread of foreign substances.

Therapeutic Messengers

Unlike liposomes and other lipid nanoparticles that seek to mimic nature, exosomes can be forward engineered to take advantage of their natural properties while being improved to deliver specific drug candidates.

Precision Engineered Exosomes

Codiak has created a proprietary platform for exosome design and manufacturing that allows for precise targeting of important molecular pathways involved with human disease.

Engineering Exosomes

engEx™ PLATFORM
Codiak has developed the technology to modify exosomes to express and deliver therapeutic drug candidates. Using our proprietary engEx™ Platform, we can effectively hijack this natural messenger system and dictate the messages that get delivered.
ENGINEERED TWO WAYS
Using our technology, exosomes are either loaded inside with potent and specific payloads or producing cells are programmed to secrete exosomes carrying drug on their surface or in their interior. These engineered messages become instructions for recipient cells.
DICTATING THE MESSAGES
Upon contact, engineered exosomes can change biological functions in recipient cells. Instructions encoded within the luminal cargo of the exosome are taken up by the cell cytosol. Instructions encoded in the exosome membrane are delivered via a protein/protein interaction at the cell surface.

We are leveraging this versatile platform technology to develop a proprietary pipeline of novel, targeted medicines for diseases with high unmet medical need.

Publications

November 9, 2018
Selective delivery of exosome-mediated STING agonist to antigen presenting cells results in significantly improved potency and reduced toxicity
September 9-12, 2018
Proteomic Characterization of Exosomes and their Impurities
May 16-19, 2018
Clinical Scale Production of Exosomes, a Novel Therapeutic Platform for the Delivery of Biomolecules
February 6, 2018
Subpopulations of Extracellular Vesicles and their Therapeutic Potential
2018
Large Scale Production and Characterization of Exosomes
2018
Continuous Manufacturing of Exosomes for Large Scale Therapeutic Applications
2018
Development of a Large Scale GMP Compliant Suspension Cell Culture System for the Manufacturing of Allogenic Exosome-based Biotherapeutics
2018
Codiak BioSciences Presents First Data on exoSTING – A Novel Engineered Exosome Therapeutic Targeting Checkpoint Refractory Tumors at the Society for Immunotherapy of Cancer’s 33rd Annual Meeting
2017
Exosome-based Biotherapeutics: Opportunities, Development and Path to Commercialization
2017
The Potential of Exosome Based Therapeutics and the Challenges of Making Them a Reality
October 26, 2017
Development of a Scalable Production Process for the Manufacturing of Exosome-based Biotherapeutics
September 27, 2017
The Opportunities and Challenges of Therapeutic Engineered Human Exosomes
June 7, 2017
Exosomes Facilitate Therapeutic Targeting of Oncogenic KRAS in Pancreatic Cancer
February 28, 2017
Development & Manufacturing of Exosomes: A New Therapeutic Modality
November 18, 2016
Stem Cell Extracellular Vesicles: Extended Messages of Regeneration.
December 31, 2015
Applying Extracellular Vesicles Based Therapeutics in Clinical Trials – an ISEV Position Paper
May 7, 2007
Exosome-Mediated Transfer Of mRNAs And MicroRNAs Is A Novel Mechanism Of Genetic Exchange Between Cells