Exosomes are nanometer-sized membrane sacs, or vesicles, that are released and received by all cells. Virtually all bodily fluids contain exosomes, and it is estimated that there are 1,000 times more exosomes than cells in our bodies.
Exosomes are an ancient system of intercellular communication, through which they deliver various molecules (DNA, RNA, proteins, lipids) from cell to cell. Upon delivery, exosomal cargo can change biological functions in recipient cells according to the instructions encoded by the payload. Exosomes do not randomly distribute, but rather appear to seek specific cellular targets, thereby offering the potential to deliver diverse therapies to specific cells and modulate cellular function to achieve therapeutic benefit.
Codiak BioSciences is taking advantage of the natural propensity of exosomes to transfer macromolecule payloads between cells. Our research covers two areas: